amyloid-beta peptides tagged posts

A boundary dance of Amyloid-beta stepping into Dementia

(a) An A-beta peptide that forms a beta-hairpin structure at the hydrophilic/hydrophobic interface. (b) View from the bottom of panel (a).
Credit: ExCELLS/IMS

Formation mechanism of the causative substances of Alzheimer’s disease revealed. Alzheimer’s disease is caused by aggregates of amyloid-beta peptides. This aggregation is accelerated at a cell membrane surface. The research group at ExCELLS revealed the reason of this phenomenon by molecular dynamics simulations and NMR experiments.

Many proteins aggregate at higher concentrations and form spherical substances called oligomers and acicular substances called amyloid fibrils...

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