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    ‘Poisoned Arrow’ Defeats Antibiotic-Resistant Bacteria

    June 5, 2020, Categories  Health/Medical, Biology/Biotechnology

    An illustration of a monstrous bacteria being punctured by molecular components of a new antibiotic
    A team of Princeton researchers led by Professor Zemer Gitai has found an antibiotic that can simultaneously puncture bacterial walls and destroy folate within their cells — taking out even monstrous bacteria with the effectiveness of a poisoned arrow — while proving immune to antibiotic resistance.
    Illustration by
    Matilda Luk, Office of Communications

    A dual-mechanism antibiotic kills Gram-negative bacteria and avoids drug resistance. Poison is lethal all on its own – as are arrows – but their combination is greater than the sum of their parts. A weapon that simultaneously attacks from within and without can take down even the strongest opponents, from E. coli to MRSA (methicillin resistant Staphylococcus aureus).

    A team of Princeton researchers reported today in the journal Cell...

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