antibiotics tagged posts

Microneedles Pierce biofilm for more effective Topical Delivery of Antibiotics to Infected Wounds

Rahim Rahimi’s flexible biodegradable microneedle array contains calcium peroxide. The microneedles pierce the biofilm layer of a wound and deliver the medicine to oxygenate the tissue and effectively eradicate biofilm infections on the wound. (Purdue University photo/Vincent Walter)

A Purdue University engineer’s patent-pending invention could improve the quality of life for millions of people suffering from diabetic foot ulcers.

Rahim Rahimi, an assistant professor in the School of Materials Engineering, has developed a flexible polymer composite microneedle array that can overcome the physicochemical bacterial biofilm present in chronic, nonhealing wounds and deliver both oxygen and bactericidal agents simultaneously...

Read More

Antibiotics may help to treat Melanoma

Eleonora Leucci: “We need more research and clinical studies to examine the use of antibiotics to treat cancer patients.” The electron microscopy image above represents a human mitochondrion, the ‘power plant’ of the cell. Image created by Roberto Vendramin. 

Some antibiotics appear to be effective against a form of skin cancer known as melanoma. Researchers at KU Leuven, Belgium, examined the effect of these antibiotics on patient-derived tumours in mice. Their findings were published in the Journal of Experimental Medicine.

Researchers from KU Leuven may have found a new weapon in the fight against melanoma: antibiotics that target the ‘power plants’ of cancer cells. These antibiotics exploit a vulnerability that arises in tumour cells when they try to survive cancer therapy.

...Read More

Deadly ‘Superbugs’ Destroyed by Molecular Drills

An illustration shows how motorized nanomachines triggered by light drill into bacteria, making a path for antibiotics. Experiments showed the bacteria became susceptible again to the antibiotic meropenem, to which it had developed resistance. Illustration by Don Thushara Galbadage

Molecular drills have gained the ability to target and destroy deadly bacteria that have evolved resistance to nearly all antibiotics. In some cases, the drills make the antibiotics effective once again.

Researchers at Rice University, Texas A&M University, Biola University and Durham (U.K.) University showed that motorized molecules developed in the Rice lab of chemist James Tour are effective at killing antibiotic-resistant microbes within minutes.

“These superbugs could kill 10 million people a ye...

Read More

Big Data from World’s Largest Citizen Science Microbiome Project serves Food for thought

American Gut Project, based at UC San Diego School of Medicine, is the world's largest crowdsourced, citizen science project. Credit: UC San Diego Health

American Gut Project, based at UC San Diego School of Medicine, is the world’s largest crowdsourced, citizen science project. Credit: UC San Diego Health

How factors such as diet, antibiotics and mental health status can influence the microbial and molecular makeup of your gut. Researchers at University of California San Diego School of Medicine and collaborators have published the first major results from the American Gut Project, a crowdsourced, global citizen science effort. The project, described May 15 in mSystems, is the largest published study to date of the human microbiome – the unique microbial communities that inhabit our bodies.

This publication provides the largest public reference database of the human gut microbiome, which may help drive many future microbiome studies...

Read More