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    At least 60 genetic diseases called Neurocutaneous disorders affect Skin, Nervous system, neurologists report

    January 22, 2016, Categories  Health/Medical, Biology/Biotechnology

    The extent and severity of manifestations of NF vary greatly from person to person and varies within the same family. Although isolated café-au-lait spots can be found in many people without NF, individuals with more than 5 of these have a good chance of also having NF1, particularly if they appear on the skin within the first 5 years of life. More than 5 café-au-lait spots are found in 1.8% of newborns, 25-40% of children and 14% of adults with NF1. Freckling under the armpits is a clear sign of NF1. After puberty, Lisch nodules are present in 97-100% of patients with NF1. Clinically, they do not cause any problems but help to confirm diagnosis. There are basically 4 types of neurofibromas found in NF1: Cutaneous: superficial, soft button-like tumours with no malignant potential Subcutaneous: tumours in the dermis that may cause localised pain or tenderness Nodular plexiform: large network of tumours involving the dorsal nerve roots Diffuse plexiform: invasive tumours that may involve all layers of skin, muscle, bone and blood vessels

    The extent and severity of manifestations of NF vary greatly from person to person and varies within the same family.
    Although isolated café-au-lait spots can be found in many people without NF, individuals with more than 5 of these have a good chance of also having NF1, particularly if they appear on the skin within the first 5 years of life. More than 5 café-au-lait spots are found in 1.8% of newborns, 25-40% of children and 14% of adults with NF1. Freckling under the armpits is a clear sign of NF1.
    After puberty, Lisch nodules are present in 97-100% of patients with NF1. Clinically, they do not cause any problems but help to confirm diagnosis.
    There are basically 4 types of neurofibromas found in NF1:
    Cutaneous: superficial, soft button-like tumours with no malignant potential
    Subcutaneous...

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