A new mouse study led by UCLA Health suggests that inflammation during pregnancy can trigger autism-like changes in offspring, but those brain and behavioral effects may be rapidly, though temporarily, reversible in adulthood with a single dose of the immunosuppressive drug rapamycin.
Even mild inflammation during midpregnancy has been shown to result in autism-like symptoms in offspring, abnormal brain growth, seizures and heightened sensitivity to everyday sensory input that persist into adulthood.
In the study published in the journal Nature Communications, UCLA researchers found that a single dose of rapamycin significantly improved brain signaling and behavioral symptoms in these offspring within about two hours, too short a time to correct ...
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