autoimmune disease tagged posts

Lab-designed molecule offers hope for celiac disease sufferers

Lab-designed molecule offers hope for coeliac disease
Credit: EMBO Molecular Medicine (2026). DOI: 10.1038/s44321-026-00430-8

A research project led by the Institute for Research in Nutrition and Food Safety (INSA) and the Faculty of Pharmacy and Food Sciences at the University of Barcelona, together with the Molecular Biology Institute of Barcelona (IBMB) of the CSIC (which stands for Consejo Superior de Investigaciones Científicas), has successfully designed and tested a gluten-degrading molecule that is a promising ally in the management of celiac disease, an autoimmune disease whose symptoms are triggered by the consumption of gluten and other prolamins found in cereals.

At present, there is a complete lack of treatment options beyond a diet free from gluten, which is difficult to maintain in Western societies where diets rely h...

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Putting the Brakes on Chronic Inflammation

Gregory Sonnenberg IBD
An overactive immune response can result in autoimmune diseases including inflammatory bowel disease, psoriasis, rheumatoid arthritis and multiple sclerosis. Credit: Ella Marushchenko and Kate Zvorykina (Ella Maru Studio)

Scientists at Weill Cornell Medicine discovered a previously unknown link between two key pathways that regulate the immune system in mammals — a finding that impacts our understanding of chronic inflammatory bowel diseases (IBD). This family of disorders severely impacts the health and quality of life of more than 2 million people in the United States.

The immune system has many pathways to protect the body from infection, but sometimes an overactive immune response results in autoimmune diseases including IBD, psoriasis, rheumatoid arthritis and multiple scler...

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Common Immune Response is found to be Protective Across Many Diseases

Common immune response protective across many diseases
Overview of study design, analytic methods, and dataset multi-omics. (A) Cartoon describing the collected single-cell and bulk multi-omic datasets with paired clinical data from infection, autoimmunity, and cancer contexts. (B) Cartoon depicting experimental and analytic strategies for single-cell and bulk data with a focus on NKG2A/C-expressing cell types. (C) Cartoon demonstrating NKG2A+ and NKG2C+ bias assignment at single-cell and bulk levels. (D) Cartoon displaying the different clinical and biological -omics to be compared between NKG2A+ and patients with an NKG2C+ bias. Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.113872

Combined, infection, autoimmunity and cancer account for 4 out of every 10 deaths worldwide, and represent major global health challenges...

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Discovery may enable an Effective Long-Term Lupus Treatment

Credit Dingzeyu Li via Unsplash.

Australian researchers have worked out how to fix a defect that causes lupus, and hope their world-first discovery will offer effective long-term treatment.

Published in Nature Communications, the Monash University-led study found a way to reprogram the defective cells of lupus patients with protective molecules from healthy people.

Using human cells, the new treatment restores the protective side of the immune system that prevents autoimmunity, which is when the immune system attacks its own cells.

The findings relate to the autoimmune disease lupus, a debilitating disease with no cure and limited treatments.

But researchers hope this new method, developed in test tubes and proven in pre-clinical models, can also be developed for other auto...

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