B cells tagged posts

The new findings could help improve vaccine effectiveness in some immunocompromised patients. Researchers at the University of Colorado Anschutz Medical Campus have uncovered a critical, previously underappreciated role for B cells in vaccine protection. Best known for producing antibodies, B cells also guide other immune cells, specifically CD8 T cells, teaching them how to mount lasting defenses after vaccination.

The study was recently published in The Journal of Clinical Investigation.

“Think of CD8 T cells as rookie firefighters,” said lead author Jared Klarquist, PhD, assistant research professor of immunology and microbiology at the University of Colorado School of Medicine. “B cells teach the class on pacing. Without them, the rookies rush in, fight hard, and quit...

A naturally occurring peptide called PEPITEM could potentially rejuvenate the immune response in older individuals and protect against ‘inflammageing’, which is widely believed to be the root cause of many age-related diseases.

The study, published today in the journal npj Aging, raises the exciting possibility of a protective agent that could dampen age-related inflammation and restore normal immune function in older adults.

PEPITEM (Peptide Inhibitor of Trans-Endothelial Migration) was initially identified at the University of Birmingham in 2015. While the role of the PEPITEM pathway has already been demonstrated in immune-mediated diseases, this is the first data showing that PEPITEM has the potential to increase healthspan in an aging population.

Researchers, led by Drs M...

For almost 140 years, the origin and behaviour of an enigmatic cell type inside lymph nodes, called a tingible body macrophage, has remained a mystery. Now, for the first time, scientists at the Garvan Institute of Medical Research have tracked the cell’s lifecycle and function, with implications for our understanding of autoimmune disorders.

Autoimmune disease, which occurs when the immune system attacks the body, affects 5% of Australians and has a high chronic health burden worldwide, yet its causes are poorly understood.

“In living organisms, death happens all the time — and if you don’t clean up, the contents of the dead cells can trigger autoimmune diseases,” says...

The immune system’s white blood cells, which are produced in the bone marrow, mostly help to defend against bacteria and injury, but sometimes they can turn against the body—for example, in cardiovascular disease, their inflammatory aggression can harm arteries and the heart. New research in Nature Immunology that was led by investigators at Massachusetts General Hospital (MGH) provides insights into the pathways that increase or decrease the bone marrow’s output of these cells. The findings may lead to new treatments for conditions that arise when the balance of white blood cell production goes awry.

Senior author Matthias Nahrendorf, MD, Ph.D...