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Could a few bad dietary choices worsen your next immune response?

Fluorescent microscopy image of mouse ear skin showing few memory T-cells in red after inflammation subsided.
Fluorescent microscopy image of mouse ear skin showing few memory T-cells in red.

Scientists have long known that diet shapes the immune system. Now, a UC San Francisco team has found that even a brief dietary change can substantially change how the body responds to skin irritation, at least in mice.

When scientists fed mice a high-fat diet for just a few days, the mice had a much worse reaction to an irritating cream. And the skin stayed on alert even after the mice returned to a low-fat diet and the inflammation cleared, responding more strongly the next time it was exposed to the cream.

The findings suggest that short-term diet may have just as much an effect as body weight when it comes to inflammation.

“Long-term dietary habits absolutely matter for health, but our study ...

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