Schematic of the preparation of hair beads (HBs) and hair follicle germs (HFGs).(A) Manual and automatic approaches to fabricate 2-μl collagen microgels containing mesenchymal cells. DP, dermal papilla cells. (B) Formation of HBs through the spontaneous constriction of collagen microgels by cell attraction forces, and the evaluation of their trichogenous activity using the patch assay. (C) Formation of an HFG composed of an HB and epithelial cell aggregate in a U-shaped microwell, and evaluation of trichogenous activity using hair generation assays.
Japanese scientists have developed an efficient method of successfully generating hair growth in nude mice...
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