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‘Brain-on-a-chip’ to test effects of biological and chemical Agents, develop countermeasures

Lawrence Livermore National Laboratory researchers Heather Enright (left) and Anna Belle hold the brain-on-a-chip device and a microelectrode array. Credit: Image courtesy of Lawrence Livermore National Laboratory

Lawrence Livermore National Laboratory researchers Heather Enright (left) and Anna Belle hold the brain-on-a-chip device and a microelectrode array. Credit: Image courtesy of Lawrence Livermore National Laboratory

Lawrence Livermore National Laboratory (LLNL) scientists and engineers have developed a “brain-on-a-chip” device aimed at testing and predicting the effects of biological and chemical agents, disease or pharmaceutical drugs on the brain over time without the need for human or animal subjects.

The device, part of the Lab’s iCHIP (in-vitro Chip-Based Human Investigational Platform) project, simulates the central nervous system by recording neural activity from multiple brain cell types deposited and grown onto microelectrode arrays...

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