Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0
Blocking enzyme PRMT5 in tumor cells could be a promising new strategy for the treatment of glioblastoma (GB), the most aggressive and lethal form of brain cancer. The researchers show that knocking down PRMT5 (protein arginine methyltransferase 5) might force the cells into senescence and slow or stop tumor growth. PRMT5 regulates gene transcription and other cell processes by transferring methyl groups and modifying chromatin. Overexpression of the enzyme in GB is associated with more aggressive disease.
The researchers showed PRMT5 inhibits the activity of a major tumor-suppressor gene called PTEN...
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