Brown fat tagged posts

Skeletal muscle signals to brain, brown fat to control aging in mice

Skeletal muscle signals to brain, brown fat to control aging in mice
The molecule mimecan — released from. Credit: skeletal muscle — helps neurons that activate brown fat maintain the length of their primary cilia (red). Restoring mimecan levels in older mice to that of younger mice helps maintain the length of the cilia and extends lifespan in older mice. Cell nuclei are in blue. Credit: Kentaro Mori

Open lines of communication between the body’s organs are important to health and often falter with age. A new study in mice by researchers at WashU Medicine shows how signals that travel from skeletal muscle to the brain and then activate brown fat and control core body temperature are weakened in elderly mice. The research suggests that finding ways to restore these signals could offer new opportunities to support healthy aging.

The study—led by S...

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A hidden “backup heater” that helps burn fat and boost metabolism

Weisensee Lab

Scientists at Washington University School of Medicine in St. Louis have uncovered a new way that brown fat, a type of fat that burns energy, can boost the body’s metabolism. This process allows cells to consume more fuel and generate heat, improving overall metabolic health. Conducted in mice, the research points to new possibilities for using brown fat to address metabolic conditions such as insulin resistance and obesity.

The findings were published Sept. 17 in Nature.

Brown fat is unique because it turns energy (calories) from food into heat. Unlike white fat, which stores energy, or muscle, which uses it immediately, brown fat helps keep the body warm in cold environments...

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Pain Receptors linked to the Generation of Energy-burning Fat cells: implications for Obesity Therapy

Brown adipocytes derived from progenitors expressing the Trpv1 receptor are labeled with Green Fluorescent Protein (GFP) and are found in brown adipose tissue of mice exposed to cold temperature. ( © Joslin Diabetes Center 2021)

A new source of energy-expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published in Nature Metabolism, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) — a protein known to sense noxious stimuli, including pain and temperature.

Specifically, the authors point to smooth muscle cells expressing the Trpv1 receptor...

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Study of 50,000 people finds Brown Fat may Protect against Many Diseases

Brown fat scan
In these PET scans, the person on the left has abundant brown fat around the neck and cervical spine. The person on the right has no detectable brown fat.
(Courtesy of Andreas G. Wibmer and Heiko Schöder)

Brown fat is that magical tissue that you would want more of. Unlike white fat, which stores calories, brown fat burns energy and scientists hope it may hold the key to new obesity treatments. But it has long been unclear whether people with ample brown fat truly enjoy better health. For one thing, it has been hard to even identify such individuals since brown fat is hidden deep inside the body.

Now, a new study in Nature Medicine offers strong evidence: among over 52,000 participants, those who had detectable brown fat were less likely than their peers to suffer cardiac and metabo...

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