cancer biomarkers tagged posts

By coating gold nanoparticles in thin layers of platinum, only a few atoms thick, Xiaohu Xia’s team was able to increase the sensitivity of test strips that detect prostate-specific antigen (PSA).
Credit: Xiaohu Xia/Michigan Tech

Identifying minute concentrations is the greatest challenge of test strips that have been developed to detect everything from cancer to infectious diseases to heart problems. The actual stripe on the paper simply isn’t sensitive enough to change color for a human eye to easily see it at concentrations that make a life-changing difference. Some nanoparticle bling could change that. And it would not greatly impact the cost of current test strips.

Gold nanoparticles have been used widely for decades for in vitro diagnostics to make medical care and treatment decisions...

Image: Dr Nuno Reis demonstrates how the disposable microfluidic test strip works.

Academics hope to boost early detection rates of cancer in developing countries with their portable lab-in-a-briefcase that can operate even at high temperatures. Believed to be the 1st kit of its kind dedicated to the portable measurement of cancer biomarkers, the concept is the brainchild of Dr Nuno Reis, a Lecturer in Chemical Engineering.

The number of people dying from cancer in developing countries is on the increase, partly due to steadily ageing populations, but also due to limited access to proper diagnostic tools. Cancer is a leading cause of death worldwide, accounting for >8 million deaths/ yr, and 70% of the world’s cancer deaths occur in Africa, Asia and Central and South America...