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    cancer cell death tagged posts

    Anti-Diarrhea Drug drives Cancer cells to Cell Death

    December 23, 2020, Categories  Health/Medical, Biology/Biotechnology

    In glioblastoma cells, the antidiarrheal drug loperamide triggers the degradation of the endoplasmic reticulum. In the normal state, it is coloured yellow in these microscopic images. In the degradation state, it glows as a red signal (marked with arrows). Left scale bar: 20 µm, right scale bar (inset): 5 µm (Photos: Svenja Zielke et. al.)

    In cell culture, loperamide, a drug commonly used against diarrhea, proves effective against glioblastoma cells. A research team has now unraveled the drug’s mechanisms of action of cell death induction and – in doing so – has shown how this compound could help attack brain 7mtumors that otherwise are difficult to treat.

    The research group led by Dr Sjoerd van Wijk from the Institute of Experimental Cancer Research in Paediatrics at Goethe Unive...

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    Synthetic Biology used to Target Cancer Cells while Sparing Healthy Tissue

    May 4, 2019, Categories  Health/Medical, Biology/Biotechnology

    (Top) some types of cancers are caused by mutated or overexpressed cell surface proteins that signal to the nucleus (green pathway) to drive uncontrolled growth and survival. (Bottom) Using an approach called RASER, the cancer-causing signals are redirected away from cell growth and survival and toward programmed cell death (orange pathway).
    Michael Lin and Stuart Jantzen

    Synthetic proteins engineered to recognize overly active biological pathways can kill cancer cells while sparing their healthy peers, according to a study by researchers at the Stanford University School of Medicine...

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