cardiovascular disease tagged posts

Highlights
•Plasma TMAO levels are elevated in type 2 diabetic patients
•Levels of the TMAO-producing enzyme FMO3 in adipose tissue correlate with obesity
•Pharmacologic and genetic inhibition of Fmo3 stimulates white adipose tissue beiging
•Inhibition of Fmo3 promotes resistance to obesity

Cleveland Clinic researchers showed that blocking a specific intestinal microbial pathway can prevent obesity and insulin resistance, as well as cause fat tissue to become more metabolically active. The team, led by J. Mark Brown, Ph.D...

Twenty-four h post-exposure change of heart rate variability (HRV) associated with PM2.5, and the intervention effect of B vitamin supplementation.

B vitamins can mitigate the impact of fine particle pollution on cardiovascular disease, according to new research at Columbia University’s Mailman School of Public Health. Healthy non-smokers who took vitamin B supplements nearly reversed any negative effects on their cardiovascular and immune systems, weakening the effects of air pollution on heart rate by 150%, total white blood count by 139%, and lymphocyte count by 106%.

The study initiates a course of research for developing preventive pharmacological interventions using B vitamins to contain the health effects of air pollution...

The degree of hair graying in male gender as an independent risk factor for coronary artery disease, a prospective study

Grey hair has been linked with an increased risk of heart disease in men, in research presented today at EuroPrevent 2017. “Ageing is an unavoidable coronary risk factor and is associated with dermatological signs that could signal increased risk,” said Dr Irini Samuel, a cardiologist at Cairo University, Egypt. Atherosclerosis and hair greying share similar mechanisms such as impaired DNA repair, oxidative stress, inflammation, hormonal changes and senescence of functional cells. This study assessed the prevalence of grey hair in patients with coronary artery disease and whether it was an independent risk marker of disease.

This was a prospective, observational study wh...

Bilirubin – Wikipedia

Mildly elevated levels of a bile pigment bilirubin may provide natural protection from heart attacks and help to stave off cardiovascular disease. The study shows that when hearts are infused with bilirubin following a heart attack, the pigment reduces damage and improves heart function during recovery.

“This is a very important finding as very few drugs are able to be administered following a heart attack to improve heart function,” says Dr Bulmer. “Generally, if it is a small heart attack people can survive. However there is a 20% mortality rate from heart attack, with approximately 50,000 heart attack sufferers each year in Australia.

“Generally, bilirubin was just associated with people having jaundice; however we have now shown that mildly elevated bilirubin is a...