CNPY2 is required for ER stress-induced Non-Alcoholic Fatty Liver Disease (NAFLD). Credit: Dr. Feng Hong of the Medical University of South Carolina.
The cell’s response to unfolded or misfolded proteins could be a cause, rather than a consequence, of metabolic disorders. The researchers identified a little-known molecule as the trigger for this response. There are links between protein-folding problems at the cellular level and a range of metabolic disorders, though it is unclear if those problems are causes or manifestations of such disorders. This study provides evidence that problems with protein folding contribute to certain metabolic disorders, according to Zihai Li, M.D., Ph.D...
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