
Principal outcomes of Nrf2 inactivation in HepG2 cells after a 24-h co-exposure to silver nanoparticles and cadmium (AgNP + Cd2+). Inhibition of Nrf2 prevented transcription of target genes, resulting in the downregulation of antioxidant defense proteins, pentose phosphate pathway (PPP) enzymes, and proteasome subunits (red arrows).
Researchers warn that a combination of nanoparticles and contaminants may form a cocktail that is harmful to our cells. In their study, 72 pct. of cells died after exposure to a cocktail of nano-silver and cadmium ions. Nanoparticles are becoming increasingly widespread in our environment. Thousands of products contain nanoparticles because of their unique properties...
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