Control Aging tagged posts

Skeletal muscle signals to brain, brown fat to control aging in mice

Skeletal muscle signals to brain, brown fat to control aging in mice
The molecule mimecan — released from. Credit: skeletal muscle — helps neurons that activate brown fat maintain the length of their primary cilia (red). Restoring mimecan levels in older mice to that of younger mice helps maintain the length of the cilia and extends lifespan in older mice. Cell nuclei are in blue. Credit: Kentaro Mori

Open lines of communication between the body’s organs are important to health and often falter with age. A new study in mice by researchers at WashU Medicine shows how signals that travel from skeletal muscle to the brain and then activate brown fat and control core body temperature are weakened in elderly mice. The research suggests that finding ways to restore these signals could offer new opportunities to support healthy aging.

The study—led by S...

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Brain Cells found to Control Aging

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature, 2017; DOI: 10.1038/nature23282

Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature, 2017; DOI: 10.1038/nature23282

Scientists at Albert Einstein College of Medicine have found that stem cells in the brain’s hypothalamus govern how fast aging occurs in the body. The finding, made in mice, could lead to new strategies for warding off age-related diseases and extending lifespan. The hypothalamus was known to regulate important processes including growth, development, reproduction and metabolism. In a 2013 Nature paper, Einstein researchers made the surprising finding that the hypothalamus also regulates aging throughout the body...

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