CRISPR gene-editing technology tagged posts

Scientists use CRISPR to edit structural gene in organism that causes leishmaniasis. Scientists are planning for Phase 1 human trials of a vaccine they developed by using CRISPR gene-editing technology to mutate the parasite that causes leishmaniasis, a skin disease common in tropical regions of the world and gaining ground in the United States.

“If you assure protection in the sand fly model, then you have a good shot at a real vaccine,” said Abhay Satoskar, a co-lead investigator of the work and professor of pathology and microbiology at The Ohio State University.

The team applied the new technology to the century-old Middle Eastern practice of le...

Researchers have found multiple applications for the CRISPR gene editing technology since it came into use by the scientific community...

CRISPR-SKIP: programmable gene splicing with single base editors. Genome Biology, 2018; 19 (1) DOI: 10.1186/s13059-018-1482-5

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated. Such targeted editing could one day be useful for treating genetic diseases caused by mutations in the genome, such as Duchenne’s muscular dystrophy, Huntington’s disease or some cancers.

CRISPR technologies typically turn off genes by breaking the DNA at the start of a targeted gene, inducing muta...