Crohn’s disease tagged posts

Scientists from the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn’s disease. This approach could become an alternative to biologic antibody therapies that carry many side effects, including increased risk of certain cancers. It might also prevent the need for surgery in the future. Findings were published in the journal Advanced Therapeutics.

Crohn’s disease is an inflammatory bowel disease characterized by chronic inflammation of the digestive tract, most often in the small intestine...

Koji Atarashi et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation, Science (2017). DOI: 10.1126/science.aan4526 Credit: CC0 Public Domain

An international team has found evidence that suggests certain types of oral bacteria may cause or exacerbate bowel disorders. In their paper published in the journal Science, the group describes testing the impact of introducing bacteria found in the mouths of humans to mice models. Xuetao Cao with the Chinese Academy of Medical Sciences offers a Perspective piece on the work done by the team in the same journal issue and suggests that the work might one day lead to the development of new kinds of treatments for common bowel disorders.

Bowel disorders such as irritable bowel syndrome, IBS, ulcerative ...

Crohn’s disease bacteria drives arthritis. E. coli bacteria (red), which are abundant in the immunoglobulin-A-coated microbiota of patients with a Crohn’s disease-associated condition called spondyloarthritis, promote systemic inflammation. The blue circular structures depict the nuclei of cells called epithelial cells. All images: Dr. Kenneth Simpson, Cornell University.

Patients with Crohn’s disease, a type of inflammatory bowel disease (IBD) that causes abdominal pain and diarrhea, can also experience joint pain. In Crohn’s disease, which affects about 800,000 Americans, the immune system can attack not only the bowels, but the musculoskeletal system as well, leading to spondyloarthritis, a painful condition that affects the spine and joints. Now new research, published Feb...

Prior AIEC colonization leads to heightened cellular and proinflammatory cytokine responses.

People who retain a particular bacterium in their gut after a bout of food poisoning may be at an increased risk of developing Crohn’s disease later in life, according to a new study led by researchers at McMaster University. Using a mouse model of Crohn’s disease, the researchers discovered that acute infectious gastroenteritis caused by common food-poisoning bacteria accelerates the growth of adherent-invasive E. coli (AIEC) – a bacterium that has been linked to the development of Crohn’s.

Even after the mice had eliminated the food-poisoning bacteria, researchers still observed increased levels of AIEC in the gut, which led to worsened symptoms over a long period of time...