Highlights •5hmC is actively enriched at endogenous DNA damage sites in cancer cell lines •DNA damage induced by aphidicolin or microirradiation increases 5hmC locally •TET2 is required to create damage-associated 5hmC foci in HeLa cells •TET enzymes promote genome integrity under replication stress in mouse ES cells
A team of scientists in Japan has found a DNA modification called 5hmC thought to be involved in turning genes on and off – localizes at sites of DNA damage and repair. They also found that a family of recently discovered enzymes, TETs for short, is important in maintaining 5hmC’s reparative role.
To turn genes on or off, a methyl group can be added to or removed from DNA. During demethylation, the methyl group is converted to 5hmC as an intermediate step...
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