diabetic neuropathy pain tagged posts

Forgotten cell clusters may hold key to diabetic neuropathy pain

Human dorsal root ganglia in a case of diabetic peripheral neuropathy show formation of Nageotte nodules (circled in pink), which appear to be a strong indicator of nerve cell death.

A phenomenon largely ignored since its discovery 100 years ago appears to be a crucial component of diabetic pain, according to new research from The University of Texas at Dallas’s Center for Advanced Pain Studies (CAPS).

Findings from a new study published in Nature Communications suggest that cell clusters called Nageotte nodules are a strong indicator of nerve cell death in human sensory ganglia. These could prove to be a target for drugs that would protect these nerves or help manage diabetic neuropathy.

“The key finding of our study is really a new view of diabetic neuropathic pain,” said Dr...

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