diabetic neuropathy tagged posts

A phenomenon largely ignored since its discovery 100 years ago appears to be a crucial component of diabetic pain, according to new research from The University of Texas at Dallas’s Center for Advanced Pain Studies (CAPS).

Findings from a new study published in Nature Communications suggest that cell clusters called Nageotte nodules are a strong indicator of nerve cell death in human sensory ganglia. These could prove to be a target for drugs that would protect these nerves or help manage diabetic neuropathy.

“The key finding of our study is really a new view of diabetic neuropathic pain,” said Dr...

In skin biopsies from the legs of healthy people (left) there are abundant sensory nerve fibers (green) but few macrophages (red). Meanwhile, in biopsies from patients with pain due to diabetic neuropathy (right), macrophages (red) surround degenerating nerve fibers (green).
Credit: Mohopatra lab

Researchers have found that inhibiting a receptor on macrophages may help relieve pain in some patients, particularly those with chronic neuropathic pain, such as those with conditions such as diabetic neuropathy. Recently, a non-opioid, investigational drug called EMA401 has shown promise as a treatment for lingering nerve pain following shingles infection...