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    Anti-Diarrhea Drug drives Cancer cells to Cell Death

    December 23, 2020, Categories  Health/Medical, Biology/Biotechnology

    In glioblastoma cells, the antidiarrheal drug loperamide triggers the degradation of the endoplasmic reticulum. In the normal state, it is coloured yellow in these microscopic images. In the degradation state, it glows as a red signal (marked with arrows). Left scale bar: 20 µm, right scale bar (inset): 5 µm (Photos: Svenja Zielke et. al.)

    In cell culture, loperamide, a drug commonly used against diarrhea, proves effective against glioblastoma cells. A research team has now unraveled the drug’s mechanisms of action of cell death induction and – in doing so – has shown how this compound could help attack brain 7mtumors that otherwise are difficult to treat.

    The research group led by Dr Sjoerd van Wijk from the Institute of Experimental Cancer Research in Paediatrics at Goethe Unive...

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