Bromodomain-protein inhibition significantly extends survival of DIPG xenograft model.
Northwestern Medicine scientists have found a molecule that stops the growth of an aggressive pediatric brain tumor. Every year, about 300 children < 10 years old in the U.S. develop a diffuse intrinsic pontine glioma (DIPG). “This tumor kills every single kid who gets DIPG within 1 year. No one survives,” said Andrea Piunti, a postdoctoral fellow in Shilatifard’s lab in biochemistry and molecular genetics at Northwestern University Feinberg School of Medicine. Radiation therapy only prolongs patients’ survival by a few months, he noted.
Shilatifard’s lab previously identified the pathway via which a mutation causes cancer in studies with fruit flies, which was published in Science a few years ago...
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