Researchers at Johns Hopkins Medicine have uncovered a critical biological mechanism that helps explain how inflammation is triggered and sustained in a wide range of diseases—highlighting a promising avenue for future therapeutic development.
The study, published in PLOS One, identified human resistin as a central driver of immune system activation. Researchers found that this protein plays a key role in turning on a powerful inflammatory pathway known as the NLRP3 inflammasome, which has been linked to numerous health conditions, including cardiovascular disease, diabetes and autoimmune disorders.
“Chronic inflammation plays a role in everything from heart disease to autoimmune disorders, yet the underlying triggers have remained unclear,” said...
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