Highlights
•SIDT2 is in endo-lysosomes and interacts with internalized double-stranded RNA
•SIDT2 promotes escape of endosomal dsRNA and cytoplasmic RLR signaling
•During HSV-1 infection, RLR signaling in bystander cells requires SIDT2
•Loss of SIDT2 impairs IFN-β production and survival after HSV-1 and EMCV infection
A discovery by Melbourne researchers has solved a longstanding mystery of how viruses trigger protective immunity within our body. A protein SIDT2 was crucial for cells to detect viral components in their environment, and initiate an immune response to reduce the virus’ spread...
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