Dynamic DNA tagged posts

SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs

Researchers have identified properties in DNA’s protective structure that could transform the way scientists think about the human genome. Molecules involved in DNA’s supportive scaffolding – once thought to be fixed – go through dynamic and responsive changes to shield against mutations, the research shows. Experts say this finding is crucial to understanding DNA damage and genome organisation and could impact current thinking on DNA-linked diseases, including cancers.
In human cells, DNA is wrapped around proteins to form chromatin. Chromatin shields DNA from damage and regulates what genetic information can be read, ie transcription.

Researchers—led by the University of Edinburgh—showe...