TRIM29 binds to and colocalizes with NEMO in the lysosome.
Houston Methodist researchers kept mice from getting the flu by removing a gene that regulates their immune system. According to a study recently published in Nature Immunology, mice missing the gene Trim29 eliminated human influenza virus within 48 hours, protecting them from infection.
“Influenza is the leading cause of death from infections worldwide. An effective treatment is vital, especially for children, the elderly and patients with compromised immune systems,” said Zhiqiang Zhang, Ph.D. “Mice lacking Trim29 kept them from a full blown infection and completely cleared them of the virus. This finding points the way to a potential flu treatment.”
Immune cells around the lungs are the first line of defense against infections...
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