epigenetic phenomenon that affects gene expression tagged posts

Highlights •In vivo tracing of parent-specific DNA methylation dynamics at single-cell resolution •Cell-type-specific methylation signatures at the Dlk-Dio3 IG-DMR during development •Dynamic parent- and cell-type-specific DNA methylation changes in the adult brain

Parental imprinting – a form of gene control passed down from parents to offspring – is far more dynamic than previously thought and may contribute to changes in the brain and other tissues over time. This finding by Whitehead Institute scientists challenges current understandings of gene regulation via DNA methylation, from development through adulthood. Methylation – attachment of methyl groups to DNA – is an epigenetic phenomenon that affects gene expression...