Loss of IL-27 signaling results in increased disease severity and lung immunopathology after SeV.
Respiratory syncytial virus (RSV) causes ~60,000 hospitalizations of children aged 0 to four, and nearly 200,000 hospitalizations and 14,000 deaths among adults 65 and older. However, there are virtually no vaccines or treatments for these infections. Perelman School of Medicine at the University of Pennsylvania and the University of Pennsylvania School of Veterinary Medicine found evidence that cytokine Interleukin 27 (IL-27), may be the key to fighting and treating these infections.
Working with a mouse-model of parainfluenza virus infection, Sendai virus, which causes similar symptoms and patterns of tissue damage to RSV, researchers found that mice fared much worse in fighting the infectio...
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