galectin-3 (Gal3) tagged posts

Highlights •Galectin-3 blood levels are elevated in human and rodent obesity •Galectin-3 directly impairs insulin action in myocytes, adipocytes, and hepatocytes •Galectin-3 treatment causes systemic insulin resistance in vivo •Galectin-3 loss of function improves insulin sensitivity in obesity

By removing the protein galectin-3 (Gal3), a team of investigators led by University of California School of Medicine researchers were able to reverse diabetic insulin resistance and glucose intolerance in mouse models of obesity and diabetes. By binding to insulin receptors on cells, Gal3 prevents insulin from attaching to the receptors resulting in cellular insulin resistance...