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    gene expression tagged posts

    Discovered: How to Unlock Inaccessible Genes

    January 29, 2016, Categories  Biology/Biotechnology

    This image shows the binding profile of chromatin remodelers on 12,000 distinct genes. The researchers used bioinformatics tools to visualize a great number of genes, here aligned by their promoters and arranged according to their nucleosome distribution. Remodelers attached to nucleosomes (dark blue verticals lines) are present on each side of the gene promoter. The researchers identified two distinct nucleosomal architectures (represented by drawings at top and bottom). Researchers demonstrated that remodeler activity depends on this nucleosome organization: some are more specifically required for expression of genes at nucleosome-dense promoters (upper part), whereas others act preferentially on promoters with a low nucleosomal density (bottom part). Credit: Matthieu Gérard, University of Paris-Sud

    This image shows the binding profile of chromatin remodelers on 12,000 distinct genes. The researchers used bioinformatics tools to visualize a great number of genes, here aligned by their promoters and arranged according to their nucleosome distribution. Remodelers attached to nucleosomes (dark blue verticals lines) are present on each side of the gene promoter. The researchers identified two distinct nucleosomal architectures (represented by drawings at top and bottom). Researchers demonstrated that remodeler activity depends on this nucleosome organization: some are more specifically required for expression of genes at nucleosome-dense promoters (upper part), whereas others act preferentially on promoters with a low nucleosomal density (bottom part)...

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    Signs of Faster Aging Process identified through Gene Research

    October 23, 2015, Categories  Health/Medical, Biology/Biotechnology

    Gene Ageing main

    An international group of researchers examined expression of genes in blood samples from 15,000 people.

    New research has shed light on the molecular changes that occur in our bodies as we age. In the largest study of its kind, an international group of researchers, including experts from the University of Exeter’s Medical School, examined expression of genes in blood samples from 15,000 people across the world.

    They found 1,450 genes that are linked to aging, and also uncovered a link between these genes and factors such as diet, smoking and exercise. Whilst the underlying causes of human aging are largely unknown, growing old increases the risk of diseases such as cancer, heart disease, and stroke — 3 of the leading causes of death.

    The research team specifically looked for changes in gen...

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