gene therapy tagged posts

In collaboration with the universities of Miami, Columbia and San Francisco, scient...

The T cell receptor on T cells might recognize antigens derived from mutated proteins in cancer cells. Once a foreign “non-self” antigen is detected, the T cell will kill the cancer cell. Credit: Matthias Leisegang.

T cell therapies with less side effects. An international team has successfully modified immune cells to recognize and specifically target tumor cells in mice. Cancer treatments based on the findings would likely have fewer side effects than standard therapies. Although T cells migrate into tumors and recognize antigens, the defense mechanism seems to fail during the formation of tumors. T cells in the tumors are usually inactive and therapeutically almost useless...

Alzheimer Disease Pathology and Site of Gene Delivery in a Patient 7 Years After Gene Transfer Credit: http://archneur.jamanetwork.com/article.aspx?articleid=2427383

The affected neurons displayed heightened growth, axonal sprouting and activation of functional markers after nerve growth factor (NGF) was injected into their brains.The findings are derived from postmortem analyses of 10 patients who participated in phase I clinical trials launched in 2001 to assess whether injected NGF – a protein essential to cellular growth, maintenance and survival – might safely slow or prevent neuronal degeneration in patients with AD.

Cholinergic Neuronal Hypertrophy and Sprouting Credit: http://archneur.jamanetwork.com/article.aspx?articleid=2427383

Administering NGF directly into the brain – a fir...