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    CRISPR-based ‘allelic drive’ allows Genetic Editing with Selective Precision and Broad Implications

    April 11, 2019, Categories  Health/Medical, Biology/Biotechnology

    Left panel: Gene-drive is mediated by a guide RNA (gRNA) that cuts at the exact site (scissors) where the gene-drive element (blue box: Cas9 gene; yellow box: gRNA) is inserted into the genome, resulting in full gene-drive element copying. Right panel: The new allelic drive is accomplished by the addition of a second gRNA (blue box) to a gene drive element that preferentially cuts a detrimental allele (scissors), but not the beneficial allele, resulting in beneficial allele copying.
    Credit: Bier Lab, UC San Diego

    Scientists developed a new version of a gene drive that allows the spread of specific, favorable genetic variants, also known as ‘alleles,’ throughout a population...

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