Mechanism of action of lactosylceramide in skin inflammation and restoration by the use of D-PDMP. Feeding a western diet raises the level of oxidized phospholipid which activates Lactosylceramide synthase (GalT-V) to generate lactosylceramide which produces reactive oxygen species-a pro-oxidant environment. Lactosylceramide also reacts with infiltrating neutrophils to activate phospholipase A-2, thus releasing arachidonic acid, eicosanoids and contributing to inflammation. This cycle of events can be broken by the judicious use of D-PDMP/BPD.
The research advances search for compounds that may someday accelerate wound healing and reverse balding...
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