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Engineers Develop a new Electrical Graphene Biosensor Chip for Detecting DNA Mutations

The biosensor chip -- consisting of a double stranded DNA probe embedded onto a graphene transistor -- electronically detects DNA SNPs. Credit: Jacobs School of Engineering, UC San Diego

The biosensor chip — consisting of a double stranded DNA probe embedded onto a graphene transistor — electronically detects DNA SNPs. Credit: Jacobs School of Engineering, UC San Diego

Researchers say the technology could one day be used in various medical applications such as blood-based tests for early cancer screening, monitoring disease biomarkers and real-time detection of viral and microbial sequences. “We are at the forefront of developing a fast and inexpensive digital method to detect gene mutations at high resolution–on the scale of a single nucleotide change in a nucleic acid sequence,” said Ratnesh Lal, professor of bioengineering, mechanical engineering and materials science in the Jacobs School of Engineering at UC San Diego.

The technology, which is at a proof-of-concept sta...

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