Linactolide
In mice, investigators found a high caloric diet turned off expression of a key hormone in the intestine, which led to deactivation of a tumor suppressor pathway. Genetic replacement of that hormone turned the tumor suppressor back on and prevented cancer development – even when mice continued to eat excess calories.
These findings position the use of the pill linaclotide (Linzess), which is structurally related to the lost hormone, as a therapeutic approach to preventing colorectal cancer in obese patients. The FDA approved linaclotide in 2012 to treat IBS with constipation as well as chronic idiopathic constipation (chronic constipation from unknown causes)...
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