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    Gut microbiome tagged posts

    Stress-induced depression
    Credit: Getty Images

    In experiments with mice and humans, a team led by Johns Hopkins Medicine researchers says it has identified a particular intestinal immune cell that impacts the gut microbiome, which in turn may affect brain functions linked to stress-induced disorders such as depression. Targeting changes mediated by these immune cells in the gut, with drugs or other therapies, could potentially bring about new ways to treat depression.

    The findings of the study were published March 20, 2023 in the journal Nature Immunology.

    “The results of our study highlight the previously unrecognized role of intestinal gamma delta T cells (γδ T cells) in modifying psychological stress responses, and the importance of a protein receptor known as dectin-1, found on the surface of immune c...

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    Gut Bacteria affect Brain Health, Mouse study shows

    January 13, 2023, Categories  Biology/Biotechnology, Health/Medical

    Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage. The study, by researchers at Washington University School of Medicine in St. Louis, indicates that gut bacteria produce compounds that influence the behavior of immune cells, including ones in the brain that can cause neurodegeneration. The findings suggest a new approach to treating Alzheimer’s and other neurodegenerative diseases. Getty Images

    Findings suggest new approach to treating Alzheimer’s, other neurodegenerative diseases. Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage...

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    New Study puts Gut Microbiome at the Center of Parkinson’s Disease Pathogenesis

    January 11, 2023, Categories  Biology/Biotechnology, Health/Medical

    Fig. 2
     PD-associated species nominated by consensus of MaAsLin2 and ANCOM-BC. Analysis included N = 724 biologically independent samples from 490 PD and 234 neurologically healthy control (NHC) subjects. a 257 species (denoted by circles in the plot) were tested in microbiome-wide association study (MWAS) with two statistical methods: MaAsLin2 and ANCOM-BC. The results are shown according to significance (−log10 of the FDR) achieved by MaAslin2 (Y-axis) vs ANCOM-BC (X-axis). Corresponding untransformed FDR values are provided in parentheses on the X and Y axes for easier interpretation. 84 species were nominated as PD-associated, defined by FDR < 0.05 by one method and FDR≤0.1 by the other: 68 achieved FDR < 0.05 by both methods, 10 achieved ANCOM-BC MaAsLin2 FDR < 0.05 by MaAsLin2 and FDR≤0...
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    Nanomaterial influences Gut Microbiome and Immune system Interactions

    December 13, 2022, Categories  Biology/Biotechnology, Health/Medical

    Decorative image
    A new study by researchers at Karolinska Institutet shows that the aryl hydrocarbon receptor (AhR) in intestinal epithelial cells senses the nanomaterial graphen oxide and activates specific immune cells known as innate lymphoid cells. Illustration by Getty Images.

    The nanomaterial graphene oxide — which is used in everything from electronics to sensors for biomolecules — can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden. The findings are reported in the journal Nature Nanotechnology.

    “This shows that we must factor the gut microbiome into our understanding of how nanomaterials affect the immune system,” says the paper’s corresponding author Bengt Fadeel, professor at the Institute o...

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