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    Gut microbiome tagged posts

    Gut Bacteria affect Brain Health, Mouse study shows

    January 13, 2023, Categories  Health/Medical, Biology/Biotechnology

    Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage. The study, by researchers at Washington University School of Medicine in St. Louis, indicates that gut bacteria produce compounds that influence the behavior of immune cells, including ones in the brain that can cause neurodegeneration. The findings suggest a new approach to treating Alzheimer’s and other neurodegenerative diseases. Getty Images

    Findings suggest new approach to treating Alzheimer’s, other neurodegenerative diseases. Gut bacteria can influence brain health, according to a study of mice genetically predisposed to develop Alzheimer’s-like brain damage...

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    New Study puts Gut Microbiome at the Center of Parkinson’s Disease Pathogenesis

    January 11, 2023, Categories  Health/Medical, Biology/Biotechnology

    Fig. 2
     PD-associated species nominated by consensus of MaAsLin2 and ANCOM-BC. Analysis included N = 724 biologically independent samples from 490 PD and 234 neurologically healthy control (NHC) subjects. a 257 species (denoted by circles in the plot) were tested in microbiome-wide association study (MWAS) with two statistical methods: MaAsLin2 and ANCOM-BC. The results are shown according to significance (−log10 of the FDR) achieved by MaAslin2 (Y-axis) vs ANCOM-BC (X-axis). Corresponding untransformed FDR values are provided in parentheses on the X and Y axes for easier interpretation. 84 species were nominated as PD-associated, defined by FDR < 0.05 by one method and FDR≤0.1 by the other: 68 achieved FDR < 0.05 by both methods, 10 achieved ANCOM-BC MaAsLin2 FDR < 0.05 by MaAsLin2 and FDR≤0...
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    Nanomaterial influences Gut Microbiome and Immune system Interactions

    December 13, 2022, Categories  Health/Medical, Biology/Biotechnology

    Decorative image
    A new study by researchers at Karolinska Institutet shows that the aryl hydrocarbon receptor (AhR) in intestinal epithelial cells senses the nanomaterial graphen oxide and activates specific immune cells known as innate lymphoid cells. Illustration by Getty Images.

    The nanomaterial graphene oxide — which is used in everything from electronics to sensors for biomolecules — can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden. The findings are reported in the journal Nature Nanotechnology.

    “This shows that we must factor the gut microbiome into our understanding of how nanomaterials affect the immune system,” says the paper’s corresponding author Bengt Fadeel, professor at the Institute o...

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    The Gut Microbiome’s Supersized Role in Shaping Molecules in our Blood

    November 11, 2022, Categories  Health/Medical, Biology/Biotechnology

    Metabolites associated with both genetics and the microbiome. (A) The 20 metabolites with the highest total R² that were significantly associated with both host genetics and the microbiome. Blue and green colored bars denote individual R² values in genetics-only and microbiome-only regression models, respectively. Gray bars denote R² values from regression using joined genetics and microbiome data. 0.9% of the variance in butyrylcarnitine plasma abundance was explained by microbial features (i.e. too little to be visible in the barplot). (B) R² values obtained by either adding individual contributions of genetics and the microbiome (additive) or by performing a joint regression (joint). The difference between the two groups indicates a small, but nonetheless significant, overlap in variance explained by genetics and the microbiome. However, the variances explained by host genetics and the microbiome were largely additive. Stars denote significance (*** -p<0.001).
    Metabolites associated with both genetics and the microbiome. (A) The 20 metabolites with the highest total R² that were significantly associated with both host genetics and the microbiome. Blue and green colored bars denote individual R² values in genetics-only and microbiome-only regression models, respectively. Gray bars denote R² values from regression using joined genetics and microbiome data. 0.9% of the variance in butyrylcarnitine plasma abundance was explained by microbial features (i.e. too little to be visible in the barplot). (B) R² values obtained by either adding individual contributions of genetics and the microbiome (additive) or by performing a joint regression (joint)...
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