high fat diet tagged posts

Obesity caused by disrupted stress-hormone rhythms is metabolically very different from obesity caused by a high-fat diet, according to a new preclinical study by Weill Cornell Medicine investigators...

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

A new study by Australian researchers, out today, is challenging what we know about the causes of diabetes. The new research points to fat tissue as a source of disease, and widens our understanding beyond the traditional focus on liver and pancreas as the main culprits. The findings, uncovered in mice, are published in the high-impact journal Cell Metabolism.

The new research is centred around the surprising finding that protein kinase C epsilon (PKCε), known to be involved in diabetes, isn’t acting in the liver or the pancreas as was once assumed. Researchers have long known that PKCε is important for the development of diabetes...

NAFLD patients have augmented plasma DPP4 activity.
•Hepatocyte-specific DPP4 overexpression in mice.
(1) promotes fatty liver disease.
(2) induces hepatic insulin resistance.
(3) reduces systemic levels of active GLP-1.
(4) enhances adipose tissue expansion and inflammation.

In mice given a high-fat diet, an increased production of the enzyme DPP4* by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance. These were the findings of a current study by DZD-researchers in Potsdam and Tübingen...

High fat Diet + Vitamin A potentiation of Insulin resistance and body weight increase

Vitamin A is an essential nutrient that the human body needs to function properly. But new research presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high-fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

Researchers fed 2 groups of rats a high-fat diet for 8 weeks. One group consumed normal amounts of vitamin A (“sufficient”), while the other group ate food that lacked the nutrient (“deficient”). The research team measured the rats’ body mass (an indicator of concentration of body fat) each week...