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Inflammation can reactivate ‘sleeping’ cancer cells hidden in the bone

Inflammation can reactivate 'sleeping' cancer cells hidden in the bone
A nest of dormant cancer cells in the bone, in magenta. Bone marrow cells are in blue and blood vessels in green. Credit: Tatiana Rizou, as in Cell Reports (2026). 

The spread of cancer from a primary tumor to another place in the body, called metastasis, remains one of the greatest challenges in cancer treatment and is responsible for most cancer-related deaths.

“Cancer cells that have moved to another part of the body can stay dormant for years after the original tumor has been treated,” explains Crick group leader Ilaria Malanchi, who leads a lab studying how cancer cells interact with the rest of the body. “It’s a worrying period for people, as they don’t know if these metastatic cells will reactivate, leading to a relapse.”

Breast cancer cells often spread to the bone marro...

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