immune response tagged posts

Researchers find a New Class of Biomarkers to Predict Treatment Outcomes in Cancer Patients

Researchers find a new of biomarkers to predict treatment outcomes in cancer patients
Cancer is the result of the uncontrolled division and spread of cells into surrounding tissue. Recently researchers have begun to focus on biomarkers as a source of information about different cancers, how they work in the body, and how they can be fought. Credit: Colin Behrens/Pixabay, CC0 Public Domain

One of the big reasons that cancer is difficult to treat is that patients respond to treatments differently, and these differences can rarely be anticipated. In most cases, determining whether and how a patient will respond to any given therapy requires administering it to the patient and then waiting and watching. That is a lot of pressure for researchers and physicians and a lot of risk for cancer patients, and added expense.

If a patient’s response were predictable, optimal thera...

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Obesity: A Dangerous Immune Response

Vasculature in murine visceral adipose tissue (red: blood vessels, green: pDCs, blue: hematopoietic cells)

Researchers show which molecular processes promote secondary diseases in obesity. Obesity and overweight are among the biggest health challenges of the 21st century, according to the World Health Organization (WHO). Almost 60 percent of Germans are considered overweight, while 25 percent are obese. Moreover, being overweight often triggers severe secondary diseases such as diabetes, arteriosclerosis, or heart attacks.

Immunological processes determine the course of this disease. As part of a new study, a group of LMU researchers led by Dr...

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All gas, no brakes: Testosterone may act as ‘Brake Pedal’ on Immune Response

In doing so, a researcher has found it could protect men from stomach inflammation. Autoimmune diseases have something in common with horses, bachelor’s degrees and daily flossing habits: women are more likely to have them.

One reason for autoimmune diseases’ prevalence in women may be sex-based differences in inflammation. In a new study, West Virginia University researcher Jonathan Busada investigated how sex hormones affect stomach inflammation in males and females. He found that androgens — or male sex hormones — may help to keep stomach inflammation in check.

“Stomach cancer is primarily caused by rampant inflammation,” said Busada, an assistant professor in the School of Medicine and researcher with the Cancer Institute...

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‘Relaxed’ T Cells Critical to Immune Response

Rice University scientists’ simple model of T cell activation of the immune response shows the T cell binding, via a receptor (TCR) to an antigen-presenting cell (APC). If an invader is identified as such, the response is activated, but only if the “relaxation” time of the binding is long enough. Illustration by Hamid Teimouri

Like finding that needle in the haystack every time, your T cells manage what seems like an improbable task: Quickly finding a few invaders among the many imposters in your body to trigger its immune response.

T cells have to react fast and do so nearly perfectly to protect people from diseases. But first, they need a little “me” time.

Rice University researchers suggest that has to do with how T cells “relax” in the process of binding to ligands—shor...

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