immune system tagged posts

More than a century ago, scientists demonstrated that sleep supports the retention of memories of facts and events. Later studies have shown that slow-wave sleep, often referred to as deep sleep, is important for transforming fragile, recently formed memories into stable, long-term memories. Now, it has been shown deep sleep may also strengthen immunological memories of previously encountered pathogens.

Studies in humans have shown that long-term increases in memory T cells are associated with deep slow-wave sleep on the nights after vaccination. Taken together, the findings support the view that slow-wave sleep contributes to the formation of long-term memories of abstract, generalized information, which leads to adaptive behavioral and immunological responses...

The immune system produces antibodies finely tuned to antigens. Recent research describes how the interaction between T cells (green) and B cells (blue) allows this to take place. Bystander B cells and antigen appear in red.
Credit: Laboratory of Molecular Immunology at The Rockefeller University

Cell Division speeds up as part of antibody selection. Mechanisms that favor selection of B cells capable of producing antibodies with highest affinity for that invader. “2 of the mechanisms that allow high affinity B cells to overwhelm the others,” says Alex Gitlin.

During an infection, B + other immune cells form germinal centers in spleen and lymph nodes, where B cells evolve in a Darwinian-like fashion...