Indazole chloride tagged posts

Photo shows Hawra Karim (left) and Seema Tiwari-Woodruff. Credit: I. Pittalwala / UC Riverside

Study shows that ‘good inflammation’ promotes axon myelination. Researchers at the University of California, Riverside, now report that indazole chloride, a synthetic compound that acts on one form of the body’s estrogen receptors previously shown to reduce multiple sclerosis symptoms in mouse models, is able to do both: remyelinate (add new myelin to) damaged axons and alter the immune system.

“While additional translational studies are required, indazole chloride and similar drugs may represent a promising new avenue of treating the underlying loss of myelin in multiple sclerosis,” said Seema Tiwari-Woodruff, an associate professor of biomedical sciences in the School of Medicine, who led the m...