inflammation tagged posts

Researchers may have solved decades-old mystery behind benzodiazepine side effects

A research team led by Virginia Commonwealth University and Columbia University has gained novel insights into a protein suspected to be involved in benzodiazepine-related inflammation. (Getty Images)

Benzodiazepines like Valium and Xanax are often prescribed to treat anxiety, insomnia and seizures. While these drugs can be effective as a short-term treatment, researchers are trying to better understand the impact of benzodiazepines after extended use.

Some experts believe long-term use of the medication may influence inflammation levels in our bodies, as previous research has shown that benzodiazepines may increase the risk of developing or worsening inflammatory conditions, like lung inflammation and inflammatory bowel disease...

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Study Offers New Detail on how COVID-19 Affects the Lungs

An illustration of ferroptosis in the lungs of a COVID-19 patient.
In some severe cases of COVID-19, the lungs undergo extreme damage, resulting in a range of life-threatening conditions like pneumonia, inflammation, and acute respiratory distress syndrome. The root cause of those wide-ranging reactions in the lungs has until now remained unclear.

New research shows that ferroptosis, a form of cell death, occurs in severe COVID-19 patient lungs. Stopping it improves outcomes. In some severe cases of COVID-19, the lungs undergo extreme damage, resulting in a range of life-threatening conditions like pneumonia, inflammation, and acute respiratory distress syndrome. The root cause of those wide-ranging reactions in the lungs has until now remained unclear.

A new study by researchers at Columbia and the Columbia University Irving Medical Center sheds l...

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New insights revealed on Tissue-Dependent roles of JAK Signaling in Inflammation

jak
Mice engineered with a patient gene (JAK1 GOF: Neuron) show less lung inflammation, fewer immune cells, and reduced mucous production compared to controls. Image Credit: Kim et al., Cell.

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues. Their findings suggest a more precise approach is required to potentially expand JAK inhibitor use to a wider range of allergy and inflammatory disorders. Details on the findings were published in the December 21, 2023, issue of the journal Cell.

JAK1 is a key protein in the body that supports cell communication and controls the immune system.

It is part of a group of proteins that pass signals ...

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New Injectable Cell Therapy could Resolve Osteoarthritis

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have created a promising injectable cell therapy to treat osteoarthritis that both reduces inflammation and also regenerates articular cartilage. Recently identified by the Food and Drug Administration as a public health crisis, osteoarthritis affects more than 520 million people worldwide who deal with pain and inflammation. Osteoarthritis is typically induced by mechanical or traumatic stress in the joint, leading to damaged cartilage that cannot be repaired naturally.Read More