An international research team has discovered a previously unknown mechanism that plays a key role in the signaling pathways involved in programmed cell death. The team identified the protein HERC4 as an essential component of both TNF-induced necroptosis and apoptosis pathways—two processes that play a crucial role in maintaining cellular balance and triggering inflammatory responses.
The study, “HERC4-mediated ubiquitination licenses RIPK1 to initiate TNF-induced cell death,” was published in Nature Structural and Molecular Biology. The lead researchers were Dr...
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