An image of the proteoglycans that have increased in the perineuronal net (green) that surrounds nerve cells (red) in the spinal cord following injury. Proteoglycans in the net limit functional regeneration and plasticity after spinal cord injury. The chondroitinase enzyme removes the net and allows for regeneration and functional recovery, especially at chronic stages.
Promising results provide hope for humans suffering from chronic paralysis. Millions of people worldwide are living with chronic spinal cord injuries, with 250,000 to 500,000 new cases each year – most from vehicle crashes or falls. The most severe spinal cord injuries completely paralyze their victims and more than half impair a person’s ability to breathe...
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