JAK inhibitor tagged posts

New insights revealed on Tissue-Dependent roles of JAK Signaling in Inflammation

jak
Mice engineered with a patient gene (JAK1 GOF: Neuron) show less lung inflammation, fewer immune cells, and reduced mucous production compared to controls. Image Credit: Kim et al., Cell.

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues. Their findings suggest a more precise approach is required to potentially expand JAK inhibitor use to a wider range of allergy and inflammatory disorders. Details on the findings were published in the December 21, 2023, issue of the journal Cell.

JAK1 is a key protein in the body that supports cell communication and controls the immune system.

It is part of a group of proteins that pass signals ...

Read More