JY231 tagged posts

A single IV treatment retrains immune cells to fight autoimmune diseases in early trial

Scientists use single injection to retrain immune cells to fight auto-immune diseases from within
In 16 patients with hard-to-treat neurological autoimmune disorders, a single infusion of JY231 generated CAR T cells inside the body. Credit: Pexels.

CAR T-cell therapy is an immune-reprogramming procedure that turns a patient’s own immune cells into cancer-fighting specialists. The entire process is complex, but researchers have now found a faster way to achieve similar effects using a single intravenous (IV) drip of a harmless engineered virus.

In the standard process, clinicians extract T cells from the patient’s blood, then re-engineer them in the lab, arming each one with a chimeric antigen receptor (CAR)—engineered proteins designed to recognize specific markers on cancer cells...

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